During his trip, the prince visited the British-established Medical Research Council (MRC) and The Gambia Armed Forces Training School in Fajara, after being treated to a state banquet at State House in Banjul.
Yesterday, the royal duo left for their tour of West Africa, just days after Prince Harry and Meghan returned from their Australian tour.
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"Their Royal Highnesses' visit to Ghana comes at an opportune moment", said British High Commissioner, H.E. Iain Walker in a press statement.
He expressed the confidence that the visit of the Prince was a great indication of how the United Kingdom wanted to scale up its trade relations with Ghana.
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He said Ghana was influenced by British values and institutional arrangements and that a large number of Ghanaians had been living in the UK.
The British Royals would on Saturday visit the Asantehene Otumfour Osei Tutu II at the Manhyia palace and subsequently visit the Christianborg Castle which was once owned by the British.
Prince Charles and Camilla attended a welcome ceremony where they met the president of Ghana Nana Addo Dankwa Akufo-Addo and the first lady, Rebecca Akufo-Addo.
Britain's Prince Charles, Prince of Wales (R) is welcomed by Gambia's President Adama Barrow (L), upon his arrival at the airport in Banjul, for an official visit.
After the welcome remarks by President Akufo-Addo, the meeting between him and Prince Charles retired into a closed-door session.
He will also meet with key players in Ghana's cocoa industry where he will discuss innovative ways to sustain one of the country's most profitable resources.