Saturday's 3-1 win over Chelsea lifted Spurs into third, three points clear of Arsenal in fifth, while Christian Eriksen's victor in the narrow 1-0 win over Inter provided a shot in the arm to the club's faltering Champions League campaign.
Spurs have taken four points from four Champions League games this season. Three games in a week is going to be tough, but confidence is high.
The decisive fixture will be made more hard for the north Londoners due to the absence of Juan Foyth from their squad.
With Spurs in the midst of a congested fixture list, the return of defender Jan Vertonghen after missing the last 10 games is timely.
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Teams are limited to 17 non-locally trained players in the competition, and Spurs have 20 in their first team squad, so Foyth, Georges-Kevin Nkoudou and Vincent Janssen have been unavailable throughout the group stage.
"It's a mistake we made, that at this level of football we can not repeat", Pochettino said, as reported by the BBC. "We need to arrive that way in Barcelona". Every three days playing games is so tough - so tough for us but for our players so so hard. Of course now that is the problem and it's so painful to have players out of the list. "We are very disappointed with the result, we'll go into the next game and see what happens", Spalletti told Sky Sport Italia.
Mauricio Pochettino will be hoping his players can use their emphatic 3-1 victory over London rivals Chelsea on Sunday to spur them on against Nerazzurri.
Fellow full-back Trippier has also been nursing his own groin issue recently and although he won't be in contention to face Inter Milan, the right-back is in the final stages of his rehabilitation so he shouldn't be on the sidelines for too much longer.
And this latest act of European escapology means second placed Tottenham are now level on points with third placed Inter.