Mexican drug lord Joaquin "El Chapo" Guzman's trial started on Monday with the selection of jurors in Brooklyn federal court.
USA prosecutors have spent years piecing together a sweeping case against Guzman, which they hope will end with the 61-year-old spending the rest of his life in a maximum-security United States prison.
Joaquin "El Chapo" Guzman is escorted to a helicopter in handcuffs by Mexican navy marines at a navy hanger in Mexico City in 2014. There are extra precautions being taken for witnesses and jurors to ensure their safety, as well.
Jury selection will take place amid tight security conditions reserved only for the most unsafe defendants.
Security around Guzman has also been tight ahead of the trial.
Guzman faces life in prison, if convicted.
Guzman has pleaded not guilty to charges that his Sinaloa cartel smuggled tons of cocaine and other drugs, laundered billions of dollars and oversaw a ruthless campaign of murders and kidnappings.
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Guzman has pleaded not guilty to charges of running a massive drug-trafficking operation in North America, including money laundering, kidnapping and murder in cities throughout the United States, including Chicago, Miami and NY.
Of about 100 potential jurors, 45 were interviewed by Judge Brian Cogan yesterday, of which 17 were dismissed and no one yet impanelled. He was known internationally as the head of Mexico's Sinaloa Cartel. Jurors will also be escorted by USA marshals to court daily while remaining anonymous throughout the trial.
It is alleged that he spent a quarter of a century smuggling more than 155 tonnes of cocaine into the United States.
There were also questioned in Brooklyn's federal court about their views on the legalization of marijuana, their fluency with Spanish and their feelings toward both law enforcement and cooperating witnesses. Heroy estimates the trial will cost United States taxpayer "more than $50 million", a price tag that includes protection programs for at least some of the several hundred witnesses expected to testify.
Some of the informants have already been absorbed into the U.S. witness protection programme and given new identities and homes around the country.
Guzman has been held in solitary confinement in NY since Mexico extradited him in January 2017, one day before Donald Trump took office. Mexican authorities then recaptured the fugitive in January 2016.