Tottenham could take on Barcelona on Wednesday night with up to seven first team players missing through injury as the north London side battle against an injury crisis before the global break.
"It's a very important match, they're a fantastic opponent, but we've shown in recent years that we can beat top teams", he continued.
Cristiano Ronaldo and Messi continue to set the bar, and Kane believes that's a motivating factor.
"It's about enjoying the game tomorrow and the best player in the world in Messi", he said. When you're scoring as many goals as he is - 40, 50 or 60 goals a season - as a striker, I want to try and match that.
They should fancy their chances, too.
'Barcelona might play better than Real Madrid did last season. We must play on Monday against City and then Wednesday or Thursday and then on Saturday again.
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So give him a little slack. "This is a very, very hard moment that most people would never understand what this is about". He had held out the entire preseason and even practice this week, though he had been playing in regular season games.
"We would have been team-mates, and maybe I would have still been in Espanyol managing him".
'I'm sure Barcelona want to bounce back but it's our chance to stop them and win four games in a row, which would be great momentum for us'.
France's World Cup winning captain Hugo Lloris offered Tottenham manager Mauricio Pochettino a little ray of sunshine amid an injury crisis on the eve of their Champions League clash with Barcelona.
Spurs are without England global Dele Alli for Barca's visit, with further doubts over Hugo Lloris, Jan Vertonghen, Mousa Dembele and Christian Eriksen. We must feel strong.
Still, the Spurs boss is boosted by the return of goalkeeper Lloris for the Group B fixture in Europe, with the France global available for selection after returning to training.
"The evolution of the team is there and everyone can appreciate that and see it", Pochettino said.