China announced last night that the president of Interpol, who is one of its citizens and who vanished while on a trip home last month, had been arrested by its anti-corruption agency.
Soon after, Interpol said it had received Meng's resignation "with immediate effect". It did not say why.
In addition to his Interpol post, Meng is also a vice minister for public security in China.
The French ministry said on Friday that Mr Meng's family had not heard from him since 25 September.
China's National Supervisory Commission announced just before midnight that Meng had been detained while an unspecified law violation was being investigated.
France has received the resignation of Meng Hongwei as president of Interpol with immediate effect, according to the worldwide police agency.
Interpol says a Chinese official who was reported missing has resigned as head of the worldwide police agency.
The Interpol General Secretariat in Lyon, France received the resignation of the organization's president, Meng Hongwei, 64, effective immediately, Interpol said in a statement Sunday. Meng has been missing since he travelled to China at the end of September, his wife said.
Meng's wife has said her husband sent her an image of a knife before he disappeared.
Grace Meng, the wife of missing Interpol President Meng Hongwei, who does not want her face shown, consults her mobile phone in the lobby of a hotel in Lyon, central France, where the police agency is based, on Sun., Oct. 7, 2018.
"This is the last, last message from my husband", she said.
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That day, his wife said he sent a social media message telling her to "wait for my call", before sending a knife emoji signifying danger.
"I'm not sure what has happened to him", she said.
Presidents of Interpol are seconded from their national administrations and remain in their home post while representing the worldwide policing body.
Mr Xi has been seeking the return of officials and business people accused of fraud and corruption from overseas, sometimes with the help of Interpol in an arrangement human rights advocates say is prone to abuse.
She issued an emotional plea for global help to find her husband.
Grace Meng relayed her fears for her husband less than an hour before the disciplinary organ of China's ruling Communist Party said he was under investigation.
The French ministry, however, said that they did not have any information regarding that.
Ms Meng detailed the last messages she exchanged with her husband to reporters as part of an impassioned plea to help bring her missing husband to safety.
His case draws parallels with other high-profile detentions in China, where President Xi Jinping has launched a massive anti-corruption drive since taking office five years ago.
It's not clear exactly what sort of crimes Meng is being accused of, but it's hard to see a good outcome for either him or China.
Fearing for her safety, she spoke with her back to reporters and refused to be photographed.