Real Madrid defender Ramos also said he had no concerns about the treatment he might receive from England supporters on his first visit to the country since tangling with Liverpool forward Mohamed Salah in the Champions League final.
England take on Spain in a Nations League game, in their first home match since returning from the World Cup in Russian Federation.
Spain play their first match since the World Cup when they take on England in the Nations League live on Sky Sports on Saturday, but what can we expect for Luis Enrique's new era? However Ramos wasn't phased by the question, shrugging off any guilt over the situation. "It doesn't matter to me".
"Of course, I didn't really know him personally". My conscience is very clear. Their talents are unique to them, there aren't many players like that, so I think the challenge for Luis Enrique is to create more of a collective - and make that collective play in a way that ensures they can cope without those big players. "I am not anxious about that in the slightest". Players have been told to attend all team meals and not to bring smartphones when they are going to eat.
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Enrique was named coach of Spain after the early exit in 2018 World Cup tournament.
"We have met before as rivals". We have got on well, as we both have strong characters but it's good vibes.
"The fact we have been a reference over the past decade means that everyone knows our national team", he said.
Isco is also on board with Enrique's decision to ban phones at the dinner table, adding: "It's always good to have a little bit of discipline, not having phones at meals is a good idea to me, these days we are often more focused on machines than speaking with our team mates".