Liverpool have won their opening five league matches and are second in the table, level on points with Chelsea, and Klopp says Salah remains a "threat" to the opposition.
Having played in the Champions League in the week, we can certainly expect to see a few changes, so here are a few things to keep your eyes peeled for.
Asked whether part of the problem was that Salah was expected to repeat last season's record-breaking form, Klopp added: "Of course, of course everyone expects that, that is clear".
While he has by no means endured a torrid start to the season, Mo Salah has also not quite looked at his best and against PSG, he looked exhausted.
"He has been fantastic in defensive situations in recent games".
Liverpool made it six wins out of six with victory over Paris Saint-Germain in the Champions League and can return to the Premier League summit on Saturday with a seventh consecutive triumph, against Southampton.
"Finishing is something that you can never take for granted".
For Southampton, top scorer Danny Ings is ineligible due to the terms of the initial loan agreement that took him from Anfield to St Mary's last month.
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Southampton will be without Danny Ings as he's not allowed to play against his parent club while Manolo Gabbiadini will face a late fitness test on a hamstring injury.
"Yes, he [Firmino] is ready", Klopp said. I don't think so.
"Dejan is close. He looks really fit".
"He is not for the squad for the weekend, of course, but we will see how soon we can try to involve him again".
"Dom trains today, (for the) first time after his concussion".
The former Republic of Ireland worldwide established a reputation as one of the Premier League's most prolific strikers during his time with Tottenham, but had limited success after moving to Liverpool for £19m in 2008.
"He's a big miss for us but he is around most of the time and so is still working on the good atmosphere in and around the team".