The tournament begins Monday, Aug. 27, at the Billie Jean King National Tennis Center in NY. If he advances on schedule to the quarters, Nadal could encounter fifth-seeded Wimbledon finalist Kevin Anderson in a rematch of last year's Flushing Meadows final. Earlier this year, the Spaniard won a record 11th French Open title.
Besides Federer-Djokovic, the other possible men's quarterfinals are Nadal-Anderson, Del Potro-Dimitrov and Zverev-Cilic. Djokoivc will open against Marton Fucsovics.
Argentina's del Potro, the 2009 US Open victor, opens against a qualifier.
They've gone on to play a total of 29 times - Serena leads 17-12 - and that includes nine all-in-the-family Grand Slam finals, most recently at the 2017 Australian Open.
In the same quarter, eighth-seeded Grigor Dimitrov of Bulgaria received a nightmare draw: a first-round meeting with 2016 champion Stan Wawrinka, who received a wild card after missing past year through injury.
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Williams, who returned to competition in March after giving birth to her first child last September, earned $62,000 in winnings over the past year but received $18.1 million from an endorsement portfolio unmatched among women in sports, according to Forbes. The issue arose when Williams - a 23-time major champion and former No. 1 - was not seeded when she returned to action at the French Open in May, her first Grand Slam tournament in almost 1½ years.
"I can say I was, back a while ago, I was intimidated by Serena (Williams) because she's so big, she's huge, but with other players, no, I haven't been". This was Halep's third unsuccessful attempt to win the tournament in Cincinnati, as she lost to Williams and Spain's Garbine Muguruza in her two previous finals in 2015 and 2016.
If the sisters do play each other, the victor might face No. 1-ranked Simona Halep in the fourth round. Sloane Stephens, the defending champion, is the No. 3 seed and could face former No. 1 Victoria Azarenka in the third round.
Stephens, the third seed, faces Russian Evgeniya Rodina in the first round, with the victor to face a qualifier in the second round. Last year, Stephens beat Madison Keys in an all-American final to capture her first career Grand Slam victory. Mertens was drawn in Stephens' quarter of the bracket, setting up a potential faceoff in the fourth round.