Unfortunately for Portugal, none of the supporting cast stepped up in a match in which the team's captain, marquee player, and talisman registered just a single shot on target.
Portugal won the 2016 European Championship and came to Russian Federation with high expectations following the surprise title in France two years ago, its first in a major tournament.
As per the itinerary I crafted for myself before landing in Russian Federation, I should remain in Sochi - where I saw Cristiano Ronaldo's hat-trick heroics vs Spain on Matchday 1 - until July 8.
Cavani and Luis Suarez unlocked the Portuguese defense early with two incredible cross-field passes.
At 33, Ronaldo is still the most important player in Fernando Santos' team, but it really is a case that if you stop Ronaldo, you beat Portugal.
Cavani was forced off in his team's last-16 match against Portugal in the second half with a leg injury, in what is a worrying sign for the Uruguayans.
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35 - At the age of 35 years and 124 days, Pepe's goal made him Portugal's oldest scorer at a FIFA World Cup. Back then, Portugal lost to France and eventually finished fourth after losing to Germany in the consolation game.
That was the first goal the twice World Cup champions had conceded in the tournament in Russian Federation, but another moment of brilliance from Cavani put them back ahead seven minutes later at the packed Fisht Stadium overlooking the Black Sea. He also was almost given a red card when his elbowing of an opponent was reviewed on video.
But after more heartbreak in the World Cup, Ronaldo hinted he would speak more on the possibility of retirement in the coming weeks. He only spoke briefly with the media in Russian Federation.
"In five days we have a match and we don't have a lot of time for recovery here", said Tabarez. "He has a great potential obviously and in planning the match, especially focusing on the opponent and considering the level that every player has ... what Ronaldo has on top of the qualities is that he's the leader of that team".