Her body was removed from her apartment this morning and a post-mortem examination is expected to take place in due course.
Her relatives quickly arrived on the scene and it's believed Queen Maxima will travel to her homeland in the coming hours, according to Hello! magazine.
Inés Zorreguieta (left) is Queen Maxima of Holland's (right) younger sister.
She was the godmother to Queen Maxima's youngest daughter, 11-year-old Princess Ariane.
Máxima said in a reaction that she is "very shocked and very upset" by the news, the RVD said.
A Dutch government spokesperson told Dutch NOS TV that Zorreguieta's death appeared to have been suicide. "It is intensely sad and heartbreaking news that can hardly be comprehended for those who stay behind", Dutch Prime Minister Mark Rutte said.
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Ms Zorreguieta was a psychologist who worked for an office on social policies at the president's office.
'I wish them all the strength they need to cope with this disgusting loss. She had also worked for the social development ministry in Buenos Aires province and at a United Nations office in Panama.
The Dutch royal family did not immediately issue a statement, though Queen Maxima's scheduled state visits to Estonia, Latvia and Lithuania next week were canceled.
King Willem-Alexander of The Netherlands and Queen Maxima of The Netherlands during the official picture at the state banquet in the Grand Ducal Palace on May 23, 2018 in Luxembourg, Luxembourg.
Inés Zorreguieta, the younger sister of Queen Maxima of the Netherlands, was found dead at her home in Buenos Aires, Argentina, on Wednesday night.