That game against Liverpool comes three days before matchday one of the Champions League, meaning Spurs will definitely play their group stage matches at their new home.
The opening Manchester derby of the season takes place at the Etihad on November 10.
Claude Puel says Leicester City's maiden fixture of the 2018/19 Premier League season will be a thrilling encounter for the Club's players and fans to look forward to.
The reverse fixture could had seen City win the title against their rivals, however a second half resurgence from United saw City lose 3-2 with a Paul Pogba double and Chris Smalling goal overshadowing the first half performance.
The traditional Premier League 'Clasico' between Liverpool and United is due to be staged at Anfield on December 15, with the return taking place at Old Trafford on February 23.
A Frustratingly Brief Look at STARFIELD, Bethesda's Newest Game Franchise
The game is a "massive first-person role-playing game" and will be the second Elder Scrolls game to make it to mobile. You're forced into exile, and you'll be exploring hand-crafted and procedurally generated dungeons as you play.
A journey down to Southampton follows on 29 December and we bring in the New Year with a mouth-watering visit of Liverpool on 1 January.
Meanwhile, Cardiff City, Fulham and Wolves have all been handed potentially winnable opening assignments following their promotion to the top flight.
Celebrating Beautiful Football: We've launched an online hub dedicated to celebrating the wonderful football Pep Guardiola's team have played this year en route to winning the Premier League and Carabao Cup.
"We are excited about the season ahead and making the new stadium our new home".
"We had always meant to request a few games away at the start of the season". Tottenham make the trip to Tyneside to play Newcastle United, while Chelsea go to Huddersfield and Manchester United host Leicester City.
All dates are provisional and subject to TV requirements.